San Jose Earthquakes vs Portland Timbers prediction and betting tips on May 21 2025

Game Prediction

In the Round of 16 of the U.S. Open Cup on May 21, 2025, a match will take place between San Jose Earthquakes and Portland Timbers. The visitors have started the MLS better and are clearly eager to succeed in this tournament as well.
Our Prediction for San Jose Earthquakes vs Portland Timbers
The California club struggled last season. They earned only 21 points, finishing last by a wide margin—the next-worst team, Chicago Fire, had 30. Their current opponent from Oregon collected 47 points and competed for a wild card. However, they were comprehensively defeated 0-5 by Vancouver Whitecaps.
Both teams have improved this new season. Experienced coach Bruce Arena has joined San Jose. After starting with a couple of wins, the team then lost six out of the next eight matches. But in May, their form picked up again—they thrashed Portland Timbers, and then beat Colorado Rapids 2-0. Following that, they had draws: 3-3 with Inter Miami and 0-0 with New England Revolution. Phil Neville and his charges are winning half of their matches, allowing them to be among the leaders in the West. Their most recent games have ended in draws: 0-0 with Real Salt Lake, 1-1 with Seattle Sounders.
In the U.S. Open Cup, Espinoza and company beat Sacramento Republic 2-1, conceding a goal right on the final whistle. Their guests had a tough match on the field of Tacoma Defiance; they took the lead, then trailed 1-2, but won by scoring twice after the 80th minute, with Kelsy netting the decisive goal from the penalty spot.
San Jose Earthquakes vs Portland Timbers: Key Stats and Trends
- San Jose Earthquakes are unbeaten in their last five matches
- Portland Timbers are undefeated in four consecutive games
- Both clubs finished their last two matches in draws
San Jose Earthquakes vs Portland Timbers: Probable Starting Line-ups
San Jose Earthquakes (probable line-up): Daniel - Romney, Mounier, Floriani - Vitor Costa, Espinoza, Buda, Leroy, Harks, Jones - Arango
Portland Timbers (probable line-up): Crépeau - Bravo, Miller, Sermann, Mosquera - Ayala, Ortiz, David Costa, Alves, Moreno - Mora
Previous Matches: San Jose Earthquakes vs Portland Timbers
Portland players had won four official meetings in a row. Only this May, in San Jose, did the hosts finally win—by a big margin.
Free Prediction for San Jose Earthquakes vs Portland Timbers
The home side is given a slight advantage. However, both teams are fairly evenly matched—our pick here is "under 3.5 total goals" (odds—1.64).
Place your bets on the upcoming match and keep an eye on your team's standing in the U.S. Open Cup standings.
